Synthesis of 5-iodo-1,2,3-triazole-containing macrocycles using copper flow reactor technology.

@article{Bogdan2011SynthesisO5,
  title={Synthesis of 5-iodo-1,2,3-triazole-containing macrocycles using copper flow reactor technology.},
  author={Andrew R. Bogdan and Keith James},
  journal={Organic letters},
  year={2011},
  volume={13 15},
  pages={4060-3}
}
A new macrocyclization strategy to synthesize 12- to 31-membered 5-iodo-1,2,3-triazole-containing macrocycles is described. The macrocycles have been generated using a simple and efficient copper-catalyzed cycloaddition in flow under environmentally friendly conditions. This methodology also permits the facile, regioselective synthesis of 1,4,5… CONTINUE READING
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