Synthesis of 5-chloromethylene hydantoins and thiohydantoins

@inproceedings{Gleason2007SynthesisO5,
  title={Synthesis of 5-chloromethylene hydantoins and thiohydantoins},
  author={James L. Gleason and Tim Cernak},
  year={2007}
}
5-Chloromethylene hydantoins were prepared by condensation of ureas with chloropyruvic acid. 5-Chloromethylene thiohydantoins were prepared by chlorination of dehydroalanines followed by condensation with thiophosgene. Convenient methods for formation of aminomethylene hydantoins and thiohydantoins using N,N,N',N'-tetramethylformamidinium chloride are also reported.