Synthesis of 5(6)-dihydro-OSW-1 analogs bearing three kinds of disaccharides linking at 15-hydroxy and their antitumor activities.

@article{Guan2011SynthesisO5,
  title={Synthesis of 5(6)-dihydro-OSW-1 analogs bearing three kinds of disaccharides linking at 15-hydroxy and their antitumor activities.},
  author={Yu-yao Guan and Dan-Jun Zheng and Liang Zhou and Haixing Wang and Zheng Yan and Nan Wang and Hong Chang and Pingping She and Ping-sheng Lei},
  journal={Bioorganic \& medicinal chemistry letters},
  year={2011},
  volume={21 10},
  pages={
          2921-4
        }
}

New disaccharide blocks for OSW-1 and its analogs

A new disaccharide block for OSW-1 natural steroidal antitumor agent was described. Regioisomeric 2- and 3-O-p-methoxybenzoyl derivatives of phenyl 1-thio-β-d-xylopyranoside and phenyl

Synthesis and cytotoxic activity of two steroids: icogenin aglycone analogs

TLDR
During the process of icogenin analog research, two cytotoxic steroids were obtained: compound 4 and compound 6 casually and their in vitro antitumor activities were tested by the standard MTT assay.

Synthesis of three OSW-1 analogs with maltose side chains bearing different protection groups

TLDR
Three 16α-O-maltose OSW-1 analogs carrying three maltose side chains bearing different protections were designed and synthesized in order to simplify the synthesis of OSw-1's disaccharide side chain.

Synthesis and antiproliferative activities of OSW-1 analogues bearing 2-acylamino-xylose residues

TLDR
38 OSW-1 analogues with 2-acylamino xylose residues are synthesized and it is found that the antitumor activities could be greatly enhanced.

Effective Killing of Leukemia Cells by the Natural Product OSW-1 through Disruption of Cellular Calcium Homeostasis*

TLDR
The extremely potent activity of OSW-1 against leukemia cells and its unique mechanism of action suggest that this compound may be potentially useful in the treatment of leukemia.

Effective cytotoxic activity of OSW-1 on colon cancer by inducing apoptosis in vitro and in vivo.

TLDR
It was shown that with low toxicity on normal colonic cells, OSW-1 suppresses colon cancer cells in vitro and this inhibition was via the intrinsic apoptotic pathway, which increased cellular calcium, changed mitochondrial membrane potential, disrupted mitochondrial morphology and led to the release of cytochrome c and the activation of caspase-3.

cDNA Cloning and Expression Analysis of Farnesyl Pyrophosphate Synthase from Ornithogalum saundersiae

  • Lei GuoJ. Kong
  • Biology, Chemistry
    Zeitschrift fur Naturforschung. C, Journal of biosciences
  • 2014
TLDR
The molecular cloning and functional identification of a new full-length cDNA encoding FPPS from Ornithogalum saundersiae, a potential medicinal plant that produces a promising antitumour sterol glycoside, OSW-1, is reported.

References

SHOWING 1-10 OF 22 REFERENCES

Synthesis and antitumor activity of icogenin and its analogue.

Total synthesis of methyl protodioscin: a potent agent with antitumor activity.

TLDR
Methyl protodioscin, otherwise known as 3-O-rhamnopyranosyl, has been synthesized for the first time from diosgenin through nine steps in an overall yield of 7.8%.

OSW-1: a natural compound with potent anticancer activity and a novel mechanism of action.

TLDR
In vitro analysis revealed that OSW-1 effectively killed primary leukemia cells from chronic lymphocytic leukemia patients with disease refractory to fludarabine, and this compound is worthy of further investigation for its potential to overcome drug resistance.

Synthesis of 5,6-dihydro-OSW-1 and its antitumor activities

5,6-Dihydro-OSW-1 (1) was synthesized following our previous procedure for the total synthesis of OSW-1. This compound demonstrated slightly stronger potency than that of OSW-1 against the growth of