Synthesis of 4-acetylisocoumarin: first total syntheses of AGI-7 and sescandelin.

@article{Kim2002SynthesisO4,
  title={Synthesis of 4-acetylisocoumarin: first total syntheses of AGI-7 and sescandelin.},
  author={Sanghee Kim and Gao-jun Fan and Jaekwang Lee and Jung Joon Lee and Deukjoon Kim},
  journal={The Journal of organic chemistry},
  year={2002},
  volume={67 9},
  pages={
          3127-30
        }
}
A practical synthetic route to 4-acetylisocoumarins and the first total synthesis of AGI-7 (5) and sescandelin (4) are described. The readily available homophthalate 8 was transformed to the vinylogous amide ester 13 in high overall yield. Upon treatment of 13 with refluxing aqueous formic acid, the desired 4-acetylisocoumarin (5) and its regioisomer 3-methyl-4-formylisocoumarin (17) were produced in a 3:1 ratio. After separation of the desired product (5) from the unwanted minor isomer, the… 
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TLDR
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References

Synthesis of 4-acetylisocoumarin: first total syntheses of AGI-7 and sescandelin.
TLDR
A practical synthetic route to 4-acetylisocoumarins and the first total synthesis of AGI-7 (5) and sescandelin (4) are described and the enantioselective reduction of AGi-7 by borane in the presence of Corey's (S)-oxazaborolidine reagent afforded (+)-sesc andelin with a 93% ee.