Synthesis of 3-substituted pyrazolo[1,5-a]-pyridines by electrophilic reactions

  title={Synthesis of 3-substituted pyrazolo[1,5-a]-pyridines by electrophilic reactions},
  author={Yasuyoshi Miki and Sanae Yagi and Hiroko Hachiken and Masazumi. Ikeda},
Reactions of pyrazolo[1,5-a]pyridines with Eschenmoser's salt, activa- ted alkenes and alkynes, and chlorosulfonyl isocyanate provided general routes to 3-substituted pyrazolo[1,5-a]pyridines such as 3-dimethylami- nomethyl-and 3-(2-nitroethyl)pyrazolo[1,5-a]pyridines, 1-phenyl-3-(py- razolo[1,5-a]pyrid-3-yl)-2-propen-1-ones, 4-(pyrazolo[1,5-a]pyrid-3-yl) -3-buten-2-one, pyrazolo[1,5-a]pyridine-3-carboxamide, and pyrazolo [1,5-a]pyridine-3-carbonitrile 
9 Citations
Au(I)-catalyzed and iodine-mediated cyclization of enynylpyrazoles to provide pyrazolo[1,5-a]pyridines.
Pyrazolo[1,5-a]pyridines and 6-iodopyrazolo(4-fluorophenyl)-3-(4- pyridinyl)pyrazolo-1, 5-a-pyridine were synthesized by gold-catalyzed and iodine-mediated cyclization of enynylpyrazoles in good to excellent yields, respectively.
Pyrazolo[1,5-a]pyridines as p38 kinase inhibitors.
A convergent synthesis of substituted pyrazolo[1,5-a]pyridines has been achieved and subsequent palladium-catalyzed introduction of pyridine or de novo synthesis of pyrimidines affords inhibitors of p38 kinase.
A copper-mediated cyclization reaction of hydrazine with enediynones providing pyrazolo[1,5-a]pyridines.
2,7-Disubstituted pyrazolo[1,5-a]pyridines were synthesized in good chemical yields by the reaction of enediynones with hydrazine, followed by addition of copper chloride. This reaction can tolerate
The development of potent and selective bisarylmaleimide GSK3 inhibitors.
A novel and efficient approach to pyrazolo〔1,5-a〕-pyridine derivatives via one-pot tandem reaction
An unusual intramolecular condensation of α,β-unsaturated esters with aldehydes was discovered and the pyrazolo[1,5-a]pyridine derivatives were conveniently synthesized by this novel tandem reaction