Synthesis of 3-phenylsulfonylmethyl cyclohexylaminobenzamide-derived antagonists of CC chemokine receptor 2 (CCR2).

@article{Yang2012SynthesisO3,
  title={Synthesis of 3-phenylsulfonylmethyl cyclohexylaminobenzamide-derived antagonists of CC chemokine receptor 2 (CCR2).},
  author={Michael G. Yang and Zili Xiao and Qing Shi and Robert J. Cherney and Andrew J. Tebben and George V De Lucca and Joseph B Santella and Ruowei Mo and Mary Ellen Cvijic and Qihong Zhao and Joel C Barrish and Percy H. Carter},
  journal={Bioorganic & medicinal chemistry letters},
  year={2012},
  volume={22 3},
  pages={1384-7}
}
We report the synthesis of 3-phenylsulfonylmethyl cyclohexylaminobenzamides (4) as CCR2 inhibitors for the potential treatment of inflammatory diseases. Several of the compounds display nanomolar binding affinity for CCR2. The in vitro structure-activity relationships of 4 are described, and are also reconciled with those from the related 2… CONTINUE READING