Synthesis of 3-indolyl-2,5-dihydroxybenzoquinones.

  title={Synthesis of 3-indolyl-2,5-dihydroxybenzoquinones.},
  author={Michael C. Pirrung and Kyungho Park and Zhengtao Li},
  journal={Organic letters},
  volume={3 3},
[figure: see text] 3-Indolylquinones can be efficiently prepared by the acid-catalyzed condensation of Indoles with 2,5-dichiorobenzoquinone, followed by DDQ oxidation. The resulting dichloroquinones are hydrolyzed to the 3-indolyidihydroxybenzoquinones. The 3-indolylquinone substructure is of interest because of its presence in natural products that modulate biological processes through protein-protein interactions, including the asterriquinones. 

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