Synthesis of 3-hydroxypyridines using ruthenium-catalyzed ring-closing olefin metathesis.

@article{Yoshida2009SynthesisO3,
  title={Synthesis of 3-hydroxypyridines using ruthenium-catalyzed ring-closing olefin metathesis.},
  author={Kazuhiro Yoshida and Fumihiro Kawagoe and K. Hayashi and Shingo Horiuchi and T. Imamoto and A. Yanagisawa},
  journal={Organic letters},
  year={2009},
  volume={11 3},
  pages={
          515-8
        }
}
  • Kazuhiro Yoshida, Fumihiro Kawagoe, +3 authors A. Yanagisawa
  • Published 2009
  • Chemistry, Medicine
  • Organic letters
  • New synthetic routes to substituted 3-hydroxypyridines 6 are presented. Ring-closing olefin metathesis (RCM)/elimination and RCM/oxidation/deprotection of nitrogen-containing dienes 4 are the key processes of the routes. An application of RCM/oxidation/deprotection to the synthesis of 3-aminopyridine 13f is also described. 
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