Synthesis of 3,4-dioxocularine and aristocularine alkaloids in a convergent route from aryloxy-phenyl acetamides involving oxalyl chloride-Lewis Acid

@article{Suau2002SynthesisO3,
  title={Synthesis of 3,4-dioxocularine and aristocularine alkaloids in a convergent route from aryloxy-phenyl acetamides involving oxalyl chloride-Lewis Acid},
  author={R. Suau and R. Rico and J. M. L{\'o}pez-Romero and F. Najera and A. Ruiz and Francisco Javier Ortiz-L{\'o}pez},
  journal={Arkivoc},
  year={2002},
  volume={2002}
}
  • R. Suau, R. Rico, +3 authors Francisco Javier Ortiz-López
  • Published 2002
  • Chemistry
  • Arkivoc
    • Double cyclization of aryloxy-phenyl acetamides is promoted by oxalyl chloride/stannyl chloride and gives 3,4-dioxocularine and aristocularine alkaloids. Rearrangement of the dibenzoxepine ring prior to the second cyclization produces xanthene derivatives. The synthesized cularinoids exhibit significant activity against various tumoral cell lines. 
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