Synthesis of 3,4-dioxocularine and aristocularine alkaloids in a convergent route from aryloxy-phenyl acetamides involving oxalyl chloride-Lewis Acid
@article{Suau2002SynthesisO3, title={Synthesis of 3,4-dioxocularine and aristocularine alkaloids in a convergent route from aryloxy-phenyl acetamides involving oxalyl chloride-Lewis Acid}, author={R. Suau and R. Rico and J. M. L{\'o}pez-Romero and F. Najera and A. Ruiz and Francisco Javier Ortiz-L{\'o}pez}, journal={Arkivoc}, year={2002}, volume={2002} }
Double cyclization of aryloxy-phenyl acetamides is promoted by oxalyl chloride/stannyl chloride and gives 3,4-dioxocularine and aristocularine alkaloids. Rearrangement of the dibenzoxepine ring prior to the second cyclization produces xanthene derivatives. The synthesized cularinoids exhibit significant activity against various tumoral cell lines.
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