Synthesis of 3'-deoxy-3'-C-methyl nucleoside derivatives.

  title={Synthesis of 3'-deoxy-3'-C-methyl nucleoside derivatives.},
  author={Mohamed Aljarah and Sarah C M Couturier and Christophe Math{\'e} and Christian P{\'e}rigaud},
  journal={Bioorganic & medicinal chemistry},
  volume={16 15},
2',3'-Dideoxy-3'-C-methyl nucleosides bearing the five naturally occurring nucleic acid bases were synthesized. Additionally, the 3'-deoxy-3'-C-methyl nucleoside analogues bearing 5-aminoimidazole-4-carboxamide as well as 1,2,4-triazole-3-carboxamide moieties were prepared. The synthesis of the corresponding 2',3'-dideoxy-3'-C-methyl triazole derivative was… CONTINUE READING