Synthesis of 2beta-substituted-14-epi-previtamin D3 and testing of its genomic activity.

@article{Sawada2010SynthesisO2,
  title={Synthesis of 2beta-substituted-14-epi-previtamin D3 and testing of its genomic activity.},
  author={Daisuke Sawada and Yuya Tsukuda and Hiroshi Saito and Ken-ichiro Takagi and Eiji Ochiai and Seiichi Ishizuka and Kazuya Takenouchi and Atsushi Kittaka},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2010},
  volume={121 1-2},
  pages={20-4}
}
2beta-substituted analogs of 14-epi-previtamin D(3) were synthesized for the first time by the thermal isomerization of the corresponding 14-epi-vitamin D3 that were available using coupling reaction between the A-ring phosphine oxide derived from a chiral epoxide and CD-ring cis-hydrindanone. The VDR binding affinity and transactivation activity of… CONTINUE READING