Synthesis of 24a-Substituted Milbemycin A4 Derivatives and Their Acaricidal Activity against Tetranychus uvticae.

Abstract

A series of 24a-substituted milbemycin A4 derivatives were synthesized from 24a-hydroxymilbemycin A4, which had been obtained by the microbial oxidation of milbemycin A4. The acaricidal activity of each synthesized derivative against Tetranychus urticae was tested and some of the derivatives showed higher activity than parent milbemycin A4. Among them, 24a… (More)
DOI: 10.1271/bbb.61.806

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