Synthesis of 2-(methylsulfonyl)-5-(4-(methylsulfonyl) phenyl)-4-phenyl-1H-[5-(14)C]imidazole, a selective COX-2 inhibitor, via asymmetrical benzoins.

Abstract

4,5-Diarylimidazoles labeled with carbon-14 in the 5-position of the imidazole ring were prepared as a part of three-step sequence from 2-hydroxy-1-(4-(methylthio)phenyl)-2-phenyl[1-(14) C]ethanone as a key synthetic intermediate which has been synthesized from potassium [(14) C]cyanide.

DOI: 10.1002/jlcr.3382

Cite this paper

@article{Shirvani2016SynthesisO2, title={Synthesis of 2-(methylsulfonyl)-5-(4-(methylsulfonyl) phenyl)-4-phenyl-1H-[5-(14)C]imidazole, a selective COX-2 inhibitor, via asymmetrical benzoins.}, author={Gholamhossein Shirvani and Abbas Shockravi and Mohsen Amini and Nader Saemian}, journal={Journal of labelled compounds & radiopharmaceuticals}, year={2016}, volume={59 4}, pages={153-6} }