Synthesis of 2,6-Diaminopimelic Acid (DAP) and Its Analogues


This article reviews synthesis of 2,6-diaminopimelic acid, an important amino acid biosynthesized by bacteria and higher plants. A number of peptidoglycan fragments containing the diaminopimelic acid (DAP) residue exhibit antitumor and/or immunostimulant activity. DAP is a versatile building block of many natural and synthetic compounds with a number of potential medicinal applications. The synthesis of immunostimulants FK-156 and FK-565 is also presented.

Cite this paper

@inproceedings{Dzierzbicka2007SynthesisO2, title={Synthesis of 2,6-Diaminopimelic Acid (DAP) and Its Analogues}, author={Krystyna Dzierzbicka}, year={2007} }