Synthesis of 2-(1,2,4-oxadiazol-3-yl)quinazolin-4(3H)-ones from diaminoglyoxime-based nitrones

Abstract

Various 2-[5-(aryl)-1,2,4-oxadiazol-3-yl]quinazolin- $$4(3H)$$ 4 ( 3 H ) -ones have been synthesized from the reaction of diaminoglyoxime-based nitrones with methyl 2-aminobenzoate or 2-aminobenzamide in the presence of acetic acid at $$100\,{^\circ }\mathrm{C}$$ 100 ∘ C . The reaction was extended as a one-pot three-component approach starting from diaminoglyoxime, aldehyde and methyl 2-aminobenzoate.

DOI: 10.1007/s11030-015-9588-0

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@article{HosseinzadehKhanmiri2015SynthesisO2, title={Synthesis of 2-(1,2,4-oxadiazol-3-yl)quinazolin-4(3H)-ones from diaminoglyoxime-based nitrones}, author={Rahim Hosseinzadeh-Khanmiri and Abolghasem Moghimi and Ahmad Shaabani and Hassan Valizadeh and Seik Weng Ng}, journal={Molecular Diversity}, year={2015}, volume={19}, pages={501-510} }