Synthesis of 2-(4-hydroxyphenyl)benzofurans and their application to beta-amyloid aggregation inhibitor.

Abstract

The facile synthesis of a series of 2-(4-hydroxyphenyl)benzofurans (4a-e) is described. The one-pot reaction of 4-substituted phenols with the chloride 1 in the presence of zinc chloride afforded 3-methylthio-2-(4-acetoxyphenyl)benzofurans (2a-e). The compounds 4a-e were obtained from the hydrolysis of 2a-e followed by the desulfurization of the resulting 3… (More)

Topics

Cite this paper

@article{Choi2004SynthesisO2, title={Synthesis of 2-(4-hydroxyphenyl)benzofurans and their application to beta-amyloid aggregation inhibitor.}, author={Hong-Dae Choi and P G Seo and Byeng-Wha Son and Byoung Won Kang}, journal={Archives of pharmacal research}, year={2004}, volume={27 1}, pages={19-24} }