Synthesis of 2,3-dideoxy-2,2-difluoro-L-glycero-pentofuranosyl nucleosides.

Abstract

Various 2,3-dideoxy-2,2-difluoro-L-glycero-pentofuranosyl nucleosides were synthesized via the key intermediate, 5-O-benzoyl-2,3-dideoxy-2,2-difluoro-L-glycero-pentofuranose (6). 2,3-O-Isopropylidene-L-glyceraldehyde was coupled with ethyl bromodifluoroacetate under Reformatsky conditions to obtain the diastereomeric mixture of ethyl (4S)-3-hydroxy-3-(2,2… (More)

Topics

Cite this paper

@article{Kotra1998SynthesisO2, title={Synthesis of 2,3-dideoxy-2,2-difluoro-L-glycero-pentofuranosyl nucleosides.}, author={Lakshmi P Kotra and Mandi Newton and C. K. Chu}, journal={Carbohydrate research}, year={1998}, volume={306 1-2}, pages={69-80} }