Synthesis of 2',3'-dideoxynucleoside phosphoesters using H-phosphonate chemistry on soluble polymer support.

@article{Crauste2011SynthesisO2,
  title={Synthesis of 2',3'-dideoxynucleoside phosphoesters using H-phosphonate chemistry on soluble polymer support.},
  author={C{\'e}line Crauste and Christian P{\'e}rigaud and Suzanne Peyrottes},
  journal={The Journal of organic chemistry},
  year={2011},
  volume={76 3},
  pages={997-1000}
}
Phosphorylation of ddC and 3TC was efficiently performed on soluble poly(ethylene glycol) support. The corresponding 5'-monophosphate derivatives were obtained by oxidation of the support bound 5'-H-phosphonate intermediates. Then, di- and triphosphorylations were carried out using a carbonyldiimidazole activation step followed by nucleophilic substitution… CONTINUE READING