Synthesis of 13-Aryl Derivatives of the Sesquiterpene Lactone Argolide and their Analgesic Activity


13-Aryl-substituted derivatives of the germacranolide argolide were synthesized by a Heck reaction with arylhalides. The structure of (E)-13-(4-methoxyphenyl)-3-oxogermacra-1(10),11(13)-dien-6α,12-olide was proved by an x-ray crystal structure analysis. Analgesic activity was found in the acetic-acid writhing test for the 13-arylgermacranolides. 
DOI: 10.1007/s10600-013-0768-9


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