Synthesis of 12-amino-11-dihomodrimane Sesquiterpenoids from Norambreinolide

Abstract

A series of dihomodrimane sesquiterpenoids containing an NH2 group were synthesized. 11-Dihomodriman-8α-ol-12-one and its dehydration products, ketones with double bonds in the C7-C8 and C8-C9 positions, were prepared from commercially available norambreinolide. The oximes of the ketones were reduced by LiAlH4 to the corresponding amines. 
DOI: 10.1007/s10600-014-0986-9

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@article{Kuchkova2014SynthesisO1, title={Synthesis of 12-amino-11-dihomodrimane Sesquiterpenoids from Norambreinolide}, author={Kaleria Kuchkova and Aculina Aricu and Albero Barba and Eleutheria Sekara and Pavel F Vlad and Nicon Ungur}, journal={Chemistry of Natural Compounds}, year={2014}, volume={50}, pages={458-461} }