Synthesis of 10-substituted triazolyl artemisinins possessing anticancer activity via Huisgen 1,3-dipolar cylcoaddition.

Abstract

Most of the 10-substituted triazolylartemisinin synthesized via the Huisgen 1,3-dipolar cylcoaddition of diastereomeric 10-azidoartemisinin (5, 6, and 7) with various alkynes (a-h) exhibit strong growth inhibition activity, even at sub-micromolar concentrations, against various cancer cell lines such as DLD-1, U-87, Hela, SiHa, A172, and B16. In particular… (More)
DOI: 10.1016/j.bmcl.2008.11.067

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@article{Cho2009SynthesisO1, title={Synthesis of 10-substituted triazolyl artemisinins possessing anticancer activity via Huisgen 1,3-dipolar cylcoaddition.}, author={Sungsik Cho and Sangtae Oh and Yumi Um and Ji-hee Jung and Jungyeob Ham and Woon-Seob Shin and Seokjoon Lee}, journal={Bioorganic & medicinal chemistry letters}, year={2009}, volume={19 2}, pages={382-5} }