Synthesis of (1R,2R)- and (1S,2R)-1,2-epoxy-3-hydroxypropylphosphonates as analogues of fosfomycin.


Cyclohexylammonium (1R,2R)-1,2-epoxy-3-hydroxypropylphosphonate was conveniently synthesized from dibenzyl (1S,2R)-2,3-O-cyclohexylidene-1,2,3-trihydroxypropylphosphonate by a reaction sequence including mesylation, hydrolysis of acetal, intramolecular Williamson reaction, and hydrogenation in the presence of cyclohexylamine. For dibenzyl (1S,2R)-2,3-O… (More)
DOI: 10.1002/ardp.200900044


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@article{Wrblewski2009SynthesisO, title={Synthesis of (1R,2R)- and (1S,2R)-1,2-epoxy-3-hydroxypropylphosphonates as analogues of fosfomycin.}, author={Andrzej E. Wr{\'o}blewski and Eligia Maria Szewczyk and Irena I Bak-Sypień}, journal={Archiv der Pharmazie}, year={2009}, volume={342 9}, pages={521-7} }