Synthesis of (-)-morphine.

@article{Taber2002SynthesisO,
  title={Synthesis of (-)-morphine.},
  author={Douglass Taber and Timothy D. Neubert and Arnold L. Rheingold},
  journal={Journal of the American Chemical Society},
  year={2002},
  volume={124 42},
  pages={
          12416-7
        }
}
The preparation of the diastereomerically pure beta-tetralone ketal 4 is reported. Intramolecular alkylidene C-H insertion followed by hydrolysis of 4 proceeded to give the enantiomerically pure cyclopentene 15. The key step in this synthesis was the bis-intramolecular cyclization of keto aldehyde 2 to give the tetracyclic intermediate 20. Enone 20 was converted over several steps to (-)-morphine 1. 
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