Synthesis of (-)-morphine.
@article{Taber2002SynthesisO, title={Synthesis of (-)-morphine.}, author={D. Taber and T. D. Neubert and A. Rheingold}, journal={Journal of the American Chemical Society}, year={2002}, volume={124 42}, pages={ 12416-7 } }
The preparation of the diastereomerically pure beta-tetralone ketal 4 is reported. Intramolecular alkylidene C-H insertion followed by hydrolysis of 4 proceeded to give the enantiomerically pure cyclopentene 15. The key step in this synthesis was the bis-intramolecular cyclization of keto aldehyde 2 to give the tetracyclic intermediate 20. Enone 20 was converted over several steps to (-)-morphine 1.
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