Synthesis of (−)-Fumagillin

@article{Taber1999SynthesisO,
  title={Synthesis of (−)-Fumagillin},
  author={Douglass Taber and Thomas E. Christos and Arnold L. Rheingold and Ilia A. Guzei},
  journal={Journal of the American Chemical Society},
  year={1999},
  volume={121},
  pages={5589-5590}
}
Angiogenesis is essential to solid tumor growth. 1a,b Inhibitors of angiogenesis are therefore under active investigation as antineoplastic agents. Preliminary evidence has recently been put forward that angiogenesis inhibitors also effectively inhibit the growth of atherosclerotic plaque. 1c Fumagillin1, (eq 1) prepared by fermentation, has been a primary lead compound in these investigations. Semisynthetic derivatives such as TNP-470 2 are currently in clinical trial as antitumor agents. 2,3… Expand
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