Synthesis of (±)-6-O-methyl and 7-demethylannulatomarin

  title={Synthesis of (±)-6-O-methyl and 7-demethylannulatomarin},
  author={A. Saeed},
  journal={Journal of Asian Natural Products Research},
  pages={88 - 93}
  • A. Saeed
  • Published 2010
  • Chemistry, Medicine
  • Journal of Asian Natural Products Research
Synthesis of 6-O-methyl and 7-demethyl derivatives of annulatomarin (1) (6,8-dihydroxy-7-methoxy-3-phenyl-3,4-dihydroisocoumarin) isolated from the aerial parts of Hypericum annulatum is described. The key step involves an efficient, microwave-accelerated solvent and catalyst-free condensation of methyl benzoate with 3,4,5-trimethoxyhomophthalic acid (2) to afford 6,7,8-trimethoxy-3-phenylisocoumarin (3). Saponification of the latter to keto acid (4) followed reduction to furnish 6,7,8… Expand
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  • Chemistry, Medicine
  • Journal of Asian natural products research
  • 2006
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  • Chemistry, Medicine
  • Natural product research
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