Synthesis of β-Substituted Cyclic Enones via Phosphonium Salt-Activated, Palladium-Catalyzed Cross-Coupling of Cyclic 1,3-Diones.

@article{Yang2016SynthesisO,
  title={Synthesis of β-Substituted Cyclic Enones via Phosphonium Salt-Activated, Palladium-Catalyzed Cross-Coupling of Cyclic 1,3-Diones.},
  author={Shyh-Ming Yang and Gee-Hong Kuo and Michael David Gaul and William V. Murray},
  journal={The Journal of organic chemistry},
  year={2016},
  volume={81 8},
  pages={
          3464-9
        }
}
Phosphonium salt-activated, Pd-catalyzed Suzuki-Miyaura and Sonogashira cross-coupling reactions of cyclic 1,3-diones in the synthesis of β-substituted cyclic enones are described. These transformations exhibit good isolated yield and high generality with respect to both substrates and coupling partners. Extension of the substrate scope to cyclic 1,3-dione equivalents, such as 2-cyanocyclohexanone (4), is also briefly examined. 

Tables and Topics from this paper.

References

Publications referenced by this paper.
SHOWING 1-3 OF 3 REFERENCES

Another similar transformation involved p - toluenesulfonyl chloride ( TsCl ) activation . See : ( b )

Y. Luo, J. Wu
  • J . Org . Chem .
  • 2015

The 3 - oxocycloalken - 1 - yl triflate is rarely used directly for Suzuki − Miyaura coupling

R. D. Carpenter, A. S. Verkman
  • Org . Lett .
  • 2010

Abstracts of Papers; 228th ACS National Meeting, Philadelphia, PA

Murray, V W.
  • August 22−26,
  • 2004