Synthesis of β-H-Phosphono-α-phosphonomethyl Analogues of Nucleoside 5"-Diphosphates

Novel β-H-phosphono-α-phosphonomethyl analogues of nucleoside 5"-diphosphates were synthesized by phosphonylation of 5"-O-phosphonomethylthymidine and 9-[2-phosphonomethyloxy)ethyl]adenine with sodium pyrophoshite. The structures of the resulting individual compounds were confirmed by NMR and UV spectroscopy.