Synthesis of α-Tocopherol (Vitamin E)

@article{Karrer1938SynthesisO,
  title={Synthesis of $\alpha$-Tocopherol (Vitamin E)},
  author={Paul Karrer and H. Fritzsche and B. H. Ringier and Hugo Salomon},
  journal={Nature},
  year={1938},
  volume={141},
  pages={1057-1057}
}
WE have described1 the synthesis of a compound, obtained by letting phytyl-bromide react with trimethyl-hydroquinone. We also expressed the opinion that this substance might be the racemic form of α-tocopherol. 
A Convenient Access to (All-rac)-α-Tocopherol Acetate from Linalool and Dihydromyrcene
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The evidence to be presented may be interpreted as supporting both hypotheses, i.e., that vitamin E is effective because of its antioxidant properties, and also that d-a-tocopherol has an almost vitamin-like specificity, because it is actively retained in the blood and other tissues of the body in a specific complex which contains selenium. Expand
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