Synthesis of [18F]fluoroetanidazole: a potential new tracer for imaging hypoxia.

  title={Synthesis of [18F]fluoroetanidazole: a potential new tracer for imaging hypoxia.},
  author={Timothy J Tewson},
  journal={Nuclear medicine and biology},
  volume={24 8},
A method has been developed for the synthesis of [18F]fluoroetanidazole, a potential tracer for imaging hypoxia with positron emission tomography. The compound is prepared by an active ester coupling reaction between the 2,3,5,6-tetrafluorophenyl ester of 2-nitroimidazole acetic acid and [18F]fluoroethylamine. [18F]Fluoroethylamine is prepared from N-[2-(toluene-4-sulfonyloxy)-ethyl]-phthalimide and [18F]fluoride and purified by distillation. The overall reaction takes about 90 min and gives a… CONTINUE READING

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