Synthesis of [(3) H], [(13) C3 , (15) N], and [(14) C]SCH 900567: an inhibitor of TNF-α (tumor necrosis factor alpha) converting enzyme (TACE).

  title={Synthesis of [(3) H], [(13) C3 , (15) N], and [(14) C]SCH 900567: an inhibitor of TNF-$\alpha$ (tumor necrosis factor alpha) converting enzyme (TACE).},
  author={Sumei Ren and David Hesk and P. Mcnamara and David Koharski and Scott Borges},
  journal={Journal of labelled compounds \& radiopharmaceuticals},
  volume={57 11},
  • S. Ren, D. Hesk, S. Borges
  • Published 31 August 2014
  • Chemistry, Biology
  • Journal of labelled compounds & radiopharmaceuticals
SCH 900567 is a specific inhibitor of tumor necrosis factor-alpha converting enzyme and is a potential candidate for the treatment of rheumatoid arthritis. [(3) H]SCH 900567 was synthesized to support the initial drug metabolism and pharmacokinetics studies. Stable isotope-labeled [(13) C3 , (15) N]SCH 900567 was requested by the bioanalytical group as an internal standard for Liquid chromatography-tandem mass spectrometry (LC-MS/MS) method development as well as by the drug metabolism and… 
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