Synthesis of (Dex-HMDI)-g-PEIs as effective and low cytotoxic nonviral gene vectors.

@article{Sun2008SynthesisO,
  title={Synthesis of (Dex-HMDI)-g-PEIs as effective and low cytotoxic nonviral gene vectors.},
  author={Yun-xia Sun and Wei Dong Xiao and Si-Xue Cheng and Xianzheng Zhang and R Jin-Cong Zhuo},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2008},
  volume={128 2},
  pages={
          171-8
        }
}
Gene vectors, (dextran-hexamethylenediisocyanate)-g-polyethylenimines ((Dex-HMDI)-g-PEIs), were synthesized through grafting low molecular weight (800 Da) branched polyethylenimine (PEI) to HMDI functionalized dextrans with two different molecular weights. The buffer capabilities of (Dex-HMDI)-g-PEIs were examined by acid-base titration. The titration profiles show that both (Dex-HMDI)-g-PEIs have the similar buffer capability regardless of the different molecular weight of dextran… CONTINUE READING
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