Synthesis of (-)-viriditoxin: a 6,6'-binaphthopyran-2-one that targets the bacterial cell division protein FtsZ.

Abstract

The inhibition of bacterial cell division offers a new approach to controlling resistant bacterial infections. FtsZ is a protein of central importance to cell division that is often described as the prokaryotic homolog of tubulin because of the structural similarity of these two proteins, in spite of low sequence homology. Both proteins undergo GTP-driven… (More)
DOI: 10.1002/anie.201007298

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