Synthesis of (+/-)-Epibatidine and Its Analogues.

  title={Synthesis of (+/-)-Epibatidine and Its Analogues.},
  author={Donglu Bai and Rui Xu and Guohua Chu and Xingzu Zhu},
  journal={The Journal of organic chemistry},
  volume={61 14},
A nonopiate analgesic, epibatidine (1), isolated from the skin of the Ecuadoran poison frog was synthesized in racemic form starting from tropinone. Distinctly different from the previously published approaches, this synthesis features the novel synthesis of the 7-azabicyclo[2.2.1]heptane ring system by contraction of the tropinone skeleton viaFavorskii… CONTINUE READING