Synthesis in yeast of a functional oxidation-resistant mutant of human α1-antitrypsin

@article{Rosenberg1984SynthesisIY,
  title={Synthesis in yeast of a functional oxidation-resistant mutant of human α1-antitrypsin},
  author={Steven Rosenberg and Philip J. Barr and R. C. Najarian and R. A. Hallewell},
  journal={Nature},
  year={1984},
  volume={312},
  pages={77-80}
}
Cumulative damage to lung tissue by leukocyte elastase is thought to be responsible for the development of pulmonary emphysema, an irreversible lung disease characterized by loss of lung elasticity1–3. It is also thought to be involved in the rapidly developing and usually fatal adult respiratory distress syndrome4. The primary defence against elastase… CONTINUE READING