Synthesis from DNA of a molecule with the connectivity of a cube

@article{Chen1991SynthesisFD,
  title={Synthesis from DNA of a molecule with the connectivity of a cube},
  author={Junghuei Chen and Nadrian C. Seeman},
  journal={Nature},
  year={1991},
  volume={350},
  pages={631-633}
}
A PRINCIPAL goal of biotechnology is the assembly of novel biomaterials for analytical, industrial and therapeutic purposes. The advent of stable immobile nucleic acid branched junctions1–4 makes DNA a good candidate for building frameworks to which proteins or other functional molecules can be attached and thereby juxtaposed5–7. The addition of single-stranded 'sticky' ends8 to branched DNA molecules converts them into macromolecular valence clusters that can be ligated together1. The edges of… Expand
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