Synthesis, encapsulation and antitumor activity of new betulin derivatives.


Novel betulin derivatives were prepared and tested for their antitumor activity. Starting from 3-O-acetyl- or 3-O-methyl-betulinic aldehyde, the synthesis of C-28 ethynyl derivatives was performed; their subsequent transformation with several 1,3-dipolarophiles afforded pyrazoles and 1,2,3-triazoles. Their screening for antitumor activity was performed in a… (More)
DOI: 10.1002/ardp.201000232


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@article{Csuk2011SynthesisEA, title={Synthesis, encapsulation and antitumor activity of new betulin derivatives.}, author={Ren{\'e} Csuk and Alexander Barthel and Ronny Sczepek and Bianka Siewert and Stefan Schwarz}, journal={Archiv der Pharmazie}, year={2011}, volume={344 1}, pages={37-49} }