Synthesis, characterization and biomedical properties of UV-cured polyurethane acrylates containing a phosphorylcholine structure.

Abstract

In order to develop a simple, economical and rapid approach to incorporate 2-methacryloyloxyethyl phosphorylcholine (MPC) with other monomers without any solvent, we prepared a series of ultraviolet cured poly(urethane acrylate) (PUA) membranes containing different MPC content. Their chemical structure and surface properties were investigated by FT-IR, XPS, water swelling ratio and water contact angle measurement, while the biocompatibilities were evaluated through fibrinogen adsorptions, platelet adhesion and plasma recalcification time determination. The results demonstrate that the phosphorylcholine (PC) groups were successfully introduced into the PUA system by the UV-curing approach and the all PC-containing membranes showed better biocompatibility than those without PC moiety. The UV-curing method is potentially to be applied in the coating of medical devices which require biocompatibility and manufacturing efficiency.

DOI: 10.1163/092050611X610315

Cite this paper

@article{Xu2012SynthesisCA, title={Synthesis, characterization and biomedical properties of UV-cured polyurethane acrylates containing a phosphorylcholine structure.}, author={Yihui Xu and Anxin Dong and Yufeng Zhao and Tao Zhang and Zhengsheng Jiang and Shasha Wang and Hong Chen}, journal={Journal of biomaterials science. Polymer edition}, year={2012}, volume={23 16}, pages={2089-104} }