Synthesis by cultured human umbilical vein endothelial cells of two proteins structurally and immunologically related to platelet membrane glycoproteins IIb and IIIa

@article{Newman1986SynthesisBC,
  title={Synthesis by cultured human umbilical vein endothelial cells of two proteins structurally and immunologically related to platelet membrane glycoproteins IIb and IIIa},
  author={Peter J. Newman and Yoshichika Kawai and Robert R. Montgomery and Thomas J. Kunicki},
  journal={The Journal of Cell Biology},
  year={1986},
  volume={103},
  pages={81 - 86}
}
Human platelets participate in a number of adhesive interactions, including binding to exposed subendothelium after vascular injury, and platelet-platelet cohesion to form large aggregates. Platelet membrane glycoproteins (GP) IIb and IIIa constitute a receptor for fibrinogen that, together with fibrinogen and calcium, is largely responsible for mediating the formation of the primary hemostatic plug. Using highly specific polyclonal and monoclonal antibodies as probes, we could detect the… CONTINUE READING

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