Synthesis, biological activity, and quantitative structure-activity relationship study of azanaphthalimide and arylnaphthalimide derivatives.

Abstract

A series of quinoline derivatives as aza analogues of the naphthalene chromophore and a series of "nonfused" tricyclic aromatic systems, in particular 5-arylquinolines and 5- or 6-aryl and heteroaryl naphthalene systems, were synthesized and evaluated for growth-inhibitory properties in several human cell lines. The analysis of quantitative structure-antitumor activity relationships for the growth-inhibitory properties is also reported. Findings suggest that these compounds may not express their cytotoxicity via interaction on DNA.

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@article{Braa2004SynthesisBA, title={Synthesis, biological activity, and quantitative structure-activity relationship study of azanaphthalimide and arylnaphthalimide derivatives.}, author={Miguel F Bra{\~n}a and Ana Gradillas and Angel G{\'o}mez and Nuria Acero and Francisco Llinares and Dolores Mu{\~n}oz-Mingarro and Cristina Abradelo and Fernanda Rey-Stolle and Mercedes Yuste and Joaquin Mar{\'i}a Campos and Miguel {\'A}ngel Gallo and Antonio Garibay Espinosa}, journal={Journal of medicinal chemistry}, year={2004}, volume={47 9}, pages={2236-42} }