Synthesis, antiproliferative, and antiplatelet activities of oxime- and amide-containing quinolin-2(1H)-one derivatives.

Abstract

Certain oxime- and amide-containing quinolin-2(1H)-one derivatives were synthesized and evaluated for their antiproliferative and antiplatelet activities. These compounds were synthesized via alkylation of hydroxyl precursors followed by the reaction with NH(2)OH or NaN(3) (Schmidt reaction). The preliminary assays indicated that amide derivatives are… (More)

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@article{Chen2007SynthesisAA, title={Synthesis, antiproliferative, and antiplatelet activities of oxime- and amide-containing quinolin-2(1H)-one derivatives.}, author={I. -Li Chen and Ken-Ming Chang and Chang-Ling Miaw and Chang-Hui Liao and Jih-Jung Chen and Tai-Chi Wang}, journal={Bioorganic & medicinal chemistry}, year={2007}, volume={15 20}, pages={6527-34} }