Synthesis, antioxidant activities and urease inhibition of some new 1,2,4-triazole and 1,3,4-thiadiazole derivatives.

Abstract

New series of 4,5-disubstituted-2,4-dihydro-3H-1,2,4-triazole-3-thiones (8a-j) and 2,5-disubstituted-1,3,4-thiadiazoles (9a-h) were synthesized by dehydrative cyclization of hydrazinecarbothioamide derivatives (7a-k) by refluxing in 4N aqueous sodium hydroxide and by overnight stirring with polyphosphoric acid, respectively. The structures of the newly… (More)
DOI: 10.1016/j.ejmech.2010.08.034

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Cite this paper

@article{Khan2010SynthesisAA, title={Synthesis, antioxidant activities and urease inhibition of some new 1,2,4-triazole and 1,3,4-thiadiazole derivatives.}, author={Imtiaz A. Khan and Sajid Ali and Shahid Hameed and Nasim Hasan Rama and Muhammad Tahir Hussain and Abdul Wadood and Reaz Uddin and Zaheer ul-Haq and Ajmal Khan and Sajjad Ali and Mohammad Iqbal Choudhary}, journal={European journal of medicinal chemistry}, year={2010}, volume={45 11}, pages={5200-7} }