Synthesis, anticonvulsant activity and 3D-QSAR study of some prop-2-eneamido and 1-acetyl-pyrazolin derivatives of aminobenzothiazole.

Abstract

A series of 6-substituted-[3-substituted-prop-2-eneamido]benzothiazole 9-32 and 6-substituted-2-[(1-acetyl-5-substituted)-2-pyrazolin-3-yl]aminobenzothiazole 33-56 were synthesized using appropriate synthetic route and evaluated experimentally against maximal electroshock test. Selected compounds were evaluated for neurotoxicity, hepatotoxicity and… (More)
DOI: 10.1016/j.ejmech.2009.09.037

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Cite this paper

@article{Amnerkar2010SynthesisAA, title={Synthesis, anticonvulsant activity and 3D-QSAR study of some prop-2-eneamido and 1-acetyl-pyrazolin derivatives of aminobenzothiazole.}, author={Nikhil D. Amnerkar and Kishore P. Bhusari}, journal={European journal of medicinal chemistry}, year={2010}, volume={45 1}, pages={149-59} }