Synthesis and thermodynamics of oligonucleotides containing chirally pure R(P) methylphosphonate linkages.

@article{Reynolds1996SynthesisAT,
  title={Synthesis and thermodynamics of oligonucleotides containing chirally pure R(P) methylphosphonate linkages.},
  author={M. Reynolds and R. Hogrefe and J. A. Jaeger and D. Schwartz and T. Riley and W. B. Marvin and W. Daily and M. Vaghefi and T. Beck and S. K. Knowles and R. Klem and L. J. Arnold},
  journal={Nucleic acids research},
  year={1996},
  volume={24 22},
  pages={
          4584-91
        }
}
Methylphosphonate (MP) oligodeoxynucleotides (MPOs) are metabolically stable analogs of conventional DNA containing a methyl group in place of one of the non-bonding phosphoryl oxygens. All 16 possible chiral R(P) MP dinucleotides were synthesized and derivatized for automated oligonucleotide synthesis. These dimer synthons can be used to prepare (i) all-MP linked oligonucleotides having defined R(P) chirality at every other position (R(P) chirally enriched MPOs) or (ii) alternating R(P) MP… Expand
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