Synthesis and thermodynamics of oligonucleotides containing chirally pure R(P) methylphosphonate linkages.

@article{Reynolds1996SynthesisAT,
  title={Synthesis and thermodynamics of oligonucleotides containing chirally pure R(P) methylphosphonate linkages.},
  author={Mark Alexander Reynolds and Richard I. Hogrefe and J A Jaeger and David A. Schwartz and Tom A. D. Riley and Walter B. Marvin and William J R Daily and Morteza M Vaghefi and Tobias Beck and Susan K Knowles and Robert E Klem and Lyle J Arnold},
  journal={Nucleic acids research},
  year={1996},
  volume={24 22},
  pages={4584-91}
}
Methylphosphonate (MP) oligodeoxynucleotides (MPOs) are metabolically stable analogs of conventional DNA containing a methyl group in place of one of the non-bonding phosphoryl oxygens. All 16 possible chiral R(P) MP dinucleotides were synthesized and derivatized for automated oligonucleotide synthesis. These dimer synthons can be used to prepare (i) all-MP linked oligonucleotides having defined R(P) chirality at every other position (R(P) chirally enriched MPOs) or (ii) alternating R(P) MP… CONTINUE READING
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