Corpus ID: 56145427

Synthesis and the Inhibitory Effects of Amino Acid Derivatives of 3-O-acetyl-11-keto- beta-boswellic Acid on Acetylcholinesterase

  title={Synthesis and the Inhibitory Effects of Amino Acid Derivatives of 3-O-acetyl-11-keto- beta-boswellic Acid on Acetylcholinesterase},
  author={Farzaneh Bandehali Naeini and Samireh Esmaeili and Ali Dadras and Seyedi Seyed Mohamad and Sadegh Modaresi and Mahshid Nikpour Nezhati and Ali Afrasiabi and Gholam Hossein Riazi},
Medicinal plants with anti-oxidation, anti-inflammation and anti-depression compounds have been administered traditionally in the treatment of some human diseases. Alzheimer's disease (AD) is one of the most debilitating diseases which have no definite cure. Recently, there is a tremendous surge in demand for natural non-steroidal drugs because of their established safety and efficacy through decades of usage by various cultures. In this study, we focused on designing and synthesis of four… Expand
1 Citations
Boswellic Acids as Promising Leads in Drug Development against Alzheimer’s Disease
BAs can be considered as valuable scaffold/lead compounds for multi-targeted DMAs in anti-AD drug discovery and development based on the available in silico, in vitro, in vivo studies and clinical trials. Expand


Acetyl-11-keto-β-boswellic acid, a constituent of a herbal medicine from Boswellia serrata resin, attenuates experimental ileitis
Oral therapy with the Boswellia extract or AKBA significantly reduces macroscopic and microcirculatory inflammatory features normally associated with indomethacin administration, indicating that the anti-inflammatory actions of the Bos Wellia extract in IBD may be due in part to boswellic acids such as AKBA. Expand
Mechanism of 5-lipoxygenase inhibition by acetyl-11-keto-beta-boswellic acid.
It is concluded that acetyl-11-keto-beta-boswellic acid acts directly on the 5-lipoxygenase enzyme at a selective site for pentacyclic triterpenes that is different from the arachidonate substrate binding site. Expand
Mechanism of antiinflammatory actions of curcumine and boswellic acids.
The data suggest that boswellic acids are specific, non-redox inhibitors of leukotriene synthesis either interacting directly with 5-lipoxygenase or blocking its translocation. Expand
Boswellic acids: biological actions and molecular targets.
This review summarizes the biological actions of BAs on the cellular and molecular level and attempts to put the data into perspective of the beneficial effects manifested in animal studies and trials with human subjects related to inflammation and cancer. Expand
Acetyl-boswellic acids are novel catalytic inhibitors of human topoisomerases I and IIalpha.
This work proposes that acetyl-BA inhibit topoisomerases I and IIalpha through competition with DNA for binding to the enzyme, and demonstrates that these compounds are a unique class of dual catalytic inhibitors of human topoisomersases I or IIalpha. Expand
Effect of Boswellia serrata on Alzheimer's disease induced in rats
The treatment of AD-induced rats with aqueous infusions of B. serrata significantly ameliorates the neurodegenerative characteristics of ADs in rats, consistent with the histopathological findings in brain tissues. Expand
Boswellic acids and glucosamine show synergistic effect in preclinical anti-inflammatory study in rats.
A synergistic effect was observed in chronic inflammatory conditions when two chemical entities were administered in combination in preclinical study of boswellic acids and glucosamine in rats. Expand
Boswellic acids and malignant glioma: induction of apoptosis but no modulation of drug sensitivity
Boswellic acids are cytotoxic to malignant glioma cells at low micromolar concentrations and induce apoptosis, and synergize with the cytot toxic cytokine, CD95 ligand, in inducingglioma cell apoptosis. Expand
Anticomplementary activity of boswellic acids--an inhibitor of C3-convertase of the classical complement pathway.
  • A. Kapil, N. Moza
  • Biology, Medicine
  • International journal of immunopharmacology
  • 1992
Boswellic acids (BA), an anti-inflammatory and anti-arthritic principle/s of Boswellia serrata, were found to possess anticomplementary activity. It inhibits the in vitro immunohaemolysis ofExpand
Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study.
The data show a definite role of gum resin of Boswellia serrata in the treatment of bronchial asthma and improvement of disease as evident by disappearance of physical symptoms and signs. Expand