Synthesis and testing of a focused phenothiazine library for binding to HIV-1 TAR RNA.

@article{Mayer2006SynthesisAT,
  title={Synthesis and testing of a focused phenothiazine library for binding to HIV-1 TAR RNA.},
  author={Moriz Mayer and P. Therese Lang and Sabina Gerber and Peter B. Madrid and Irene G{\'o}mez Pinto and R. Kiplin Guy and Thomas L. James},
  journal={Chemistry & biology},
  year={2006},
  volume={13 9},
  pages={993-1000}
}
We have synthesized a series of phenothiazine derivatives, which were used to test the structure-activity relationship of binding to HIV-1 TAR RNA. Variations from our initial compound, 2-acetylphenothiazine, focused on two moieties: ring substitutions and n-alkyl substitutions. Binding characteristics were ascertained via NMR, principally by saturation transfer difference spectra of the ligand and imino proton resonance shifts of the RNA. Both ring and alkyl substitutions manifested NMR… CONTINUE READING

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