Synthesis and sulfatase inhibitory activities of non-steroidal estrone sulfatase inhibitors.

  title={Synthesis and sulfatase inhibitory activities of non-steroidal estrone sulfatase inhibitors.},
  author={Portia K Li and Salvatore Milano and L Kluth and Madeline E. Rhodes},
  journal={The Journal of steroid biochemistry and molecular biology},
  volume={59 1},
About one-third of breast cancers are classified as estrogen-dependent breast cancers. In the past 10 years, numerous reports have suggested the importance of estrone sulfate and estrone sulfatase in regulating the supply of estrogens to these cancers. Estrone sulfatase inhibitors may thus prove to be useful for the treatment of these diseases. Several research groups have reported the development of estrone sulfatase inhibitors, and estrone-3-O-sulfamate has been shown to be the most potent… CONTINUE READING


Publications citing this paper.
Showing 1-8 of 8 extracted citations

Development of steroid sulfatase inhibitors

Molecular and Cellular Endocrinology • 2011
View 3 Excerpts
Highly Influenced

Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2006
View 1 Excerpt

Similar Papers

Loading similar papers…