Synthesis and study of effect of analogs of conopressin S on excretion of ions and water by rat kidney

@article{Kutina2012SynthesisAS,
  title={Synthesis and study of effect of analogs of conopressin S on excretion of ions and water by rat kidney},
  author={Anna V Kutina and A.S. Marina and Ivan I. Eliseev and Mikhail I. Titov and Yu. V. Natochin},
  journal={Journal of Evolutionary Biochemistry and Physiology},
  year={2012},
  volume={48},
  pages={516-522}
}
There were studied effects of analogs of conopressin S—a peptide of the vasopressin family with amino acid replacement at the 2nd and 4th positions (characteristic of invertebrate peptides)—on transport of water and ions in the rat kidney. Administration to female Wistar rats of 1-deamino-conopessin S produced a weak action on water transport and had no effect on K+ and Na+ excretion. Its analog, 1-deamino-Tyr2-conopressin S, caused antidiuretic and kaliuretic action without affecting Na… 

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