Synthesis and structure-activity relationships of a series of anxioselective pyrazolopyridine ester and amide anxiolytic agents.

@article{Bare1989SynthesisAS,
  title={Synthesis and structure-activity relationships of a series of anxioselective pyrazolopyridine ester and amide anxiolytic agents.},
  author={Thomas Michael Bare and Charles David Mclaren and J. B. Jun. Campbell and Judy W. Firor and James Franklin Resch and C. Patricia Walters and Andre I. Salama and B. A. Meiners and Jitendra B. Patel},
  journal={Journal of medicinal chemistry},
  year={1989},
  volume={32 12},
  pages={
          2561-73
        }
}
A series of 1-substituted 4-amino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid esters and amides were synthesized and screened for anxiolytic activity in the shock-induced suppression of drinking (SSD) test. The compounds were also tested for their ability to displace [3H]flunitrazepam (FLU) from brain benzodiazepine (BZ) binding sites. Many compounds were active in these screens and, additionally, demonstrated a selectivity for the type 1 BZ (BZ1) receptor over the type 2 BZ (BZ2) receptor as… 
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