Synthesis and structure-activity relationships of new (5R,8R,10R)-ergoline derivatives with antihypertensive or dopaminergic activity.

@article{Ohno1994SynthesisAS,
  title={Synthesis and structure-activity relationships of new (5R,8R,10R)-ergoline derivatives with antihypertensive or dopaminergic activity.},
  author={S. Ohno and Y. Adachi and M. Koumori and K. Mizukoshi and M. Nagasaka and K. Ichihara and E. Kato},
  journal={Chemical & pharmaceutical bulletin},
  year={1994},
  volume={42 7},
  pages={
          1463-73
        }
}
A series of new (5R,8R,10R)-ergoline derivatives was synthesized, and their antihypertensive and dopaminergic activities were tested in conscious spontaneously hypertensive rats and in rats with unilateral 6-hydroxydopamine-induced lesions of the substantia nigra. (5R,8R,10R)-6-Alkyl-8-ergolinemethanols, prepared from the corresponding ergolinecarboxylates, were converted to the tosylates, which were treated with various five-membered heterocycles containing nitrogen atoms to afford the new… Expand
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